Reactive distillation places a reaction zone inside a distillation column so that products are removed from the reacting mixture as they form. For equilibrium-limited reactions this pulls conversion beyond what a separate reactor would reach, and the heat of reaction contributes to vapour generation. The technology is established for fuel ethers such as MTBE, ETBE and TAME and for esterifications, of which the methyl acetate process is the best known example, and it is widely regarded as a leading case of process intensification (Harmsen, 2007; Taylor and Krishna, 2000). The price of the integration is a loss of operating freedom. A conventional plant can correct a reactor upset in the separation train. A reactive column has to absorb the upset where it occurs.

Feedstock is the usual source of such upsets. The C4 cut fed to an etherification column changes in isobutene content with the upstream cracker or dehydrogenation unit, alcohols arrive with varying water content, and renewable acids and oils differ from batch to batch. Each change moves the economically best operating point, and the conventional control hierarchy follows it slowly. Economic model predictive control (EMPC) is the proposal to remove that delay by letting the dynamic controller optimise an economic objective directly, without the intermediate step of a setpoint (Rawlings et al., 2012; Ellis et al., 2014).

This article reviews what the published literature says about applying that idea to reactive distillation columns whose feed varies. It considers the features of the process that shape the control problem, the theory that underpins economic formulations, the available treatments of feed disturbances, the small number of reported applications, and the practical questions of computation and implementation. It reports no new simulations or plant results.

The review is narrative. It draws on journal articles, conference papers and textbooks in process control and chemical engineering that are well known in the field, selected for their bearing on the question and not through a formal search protocol. No claim of completeness is made. Preference was given to sources that state general results, such as stability conditions or structural properties of reactive columns, over those that report the tuning of a single example. Where the literature consists of simulation studies only, that is said, because the distinction between a result shown on a model and one shown on a plant matters a great deal for the conclusions that can be drawn.

Three properties of reactive columns recur in the control literature: the need to keep reactants in stoichiometric balance, the strong nonlinearity that follows from coupling reaction with phase equilibrium, and the uncertainty of the models used to describe both.

Process plants are usually operated through a hierarchy of layers that work on different time scales, shown in Figure 1. Planning and scheduling decide what to make. A real-time optimiser (RTO) solves a steady-state model for the most profitable operating point. A model predictive controller moves the plant to the resulting setpoints while respecting constraints, and regulatory loops carry out its moves (Qin and Badgwell, 2003; Darby et al., 2011).

The weaknesses of the hierarchy are well documented. The optimiser can run only when the plant is judged to be at steady state, so a unit that is disturbed frequently is optimised rarely. The optimiser and the controller use different models, and the setpoint computed by one may be unreachable or poor according to the other. Economic information about the transient itself is discarded, because the controller is asked only to reach the target quickly (Engell, 2007). One response keeps the hierarchy and chooses controlled variables whose constant setpoints give acceptable loss when disturbances occur, the self-optimising control idea of Skogestad (2000). The other response, EMPC, removes the separation between optimisation and control.

Feed variation reaches a reactive column in several forms. The concentration of the reactive component in a mixed stream changes, as with isobutene in a C4 cut. Inert components that must leave in one product change the internal traffic of the column. Trace species such as water compete in side reactions or inhibit the catalyst. Feed rate changes with upstream production. Some of these can be measured on line, at a price and with analyser delay. Others must be inferred from their effect on the column.

The literature offers four ways of handling them within a predictive controller. A measured disturbance can be included in the model as a feedforward input. An unmeasured one can be estimated together with the states, by an extended Kalman filter or by moving horizon estimation, which handles constraints and nonlinear models in the same optimisation framework as the controller (Rao et al., 2003). The controller can be made robust to a set of possible feeds, for instance by the multi-stage formulation of Lucia et al. (2013), in which a scenario tree represents the uncertainty and future control moves are allowed to depend on which branch is realised. Finally, the back-off from quality constraints can simply be enlarged. Table 1 compares the main operating strategies by the way economics enter and by their response to a feed change.

None of these approaches is specific to reactive distillation, and each has a cost there. Feedforward depends on a feed analyser that is as available as the controller itself. Estimation depends on observability: several feed components and a drifting catalyst activity cannot all be reconstructed from a handful of tray temperatures, and a wrongly attributed disturbance leads the optimiser to a wrong economic conclusion. Robust formulations multiply the size of a problem that is already large. The published work has not yet settled which combination is adequate for which class of column.

Predictive control of reactive distillation has been studied for more than two decades, mostly with tracking objectives. Khaledi and Young (2005) modelled an ETBE column and examined model predictive control of product composition and reactant conversion, a pairing that reflects the dual purpose of the unit. Work of this kind established that multivariable predictive controllers can handle the interaction between the separation and reaction objectives better than independent loops, at least in simulation.

Explicitly economic formulations are rarer. Idris and Engell (2012) investigated nonlinear predictive control strategies with economic objectives for a continuous catalytic distillation process and compared them with tracking alternatives, which makes their study one of the few to address the subject of this review directly. Beyond it, the evidence consists largely of simulation studies on benchmark etherification and esterification columns, with feed composition steps as the test disturbance. These studies agree qualitatively: an economic controller exploits the transient and moves toward the new optimum without waiting, and its advantage depends on how accurately the feed disturbance is known. The review found no detailed public account of a long-running industrial implementation, and the absence should be read as a statement about the published record and not about practice in general.

A stage-by-stage column model with reaction is a system of differential and algebraic equations with some hundreds of states. Solving a nonlinear programme over it within one sampling interval was once the main obstacle. Direct methods with structure-exploiting solvers have changed that. The real-time iteration scheme of Diehl et al. (2002), illustrated by its authors with a distillation column model, performs one Newton-type step per sample, and the advanced-step controller of Zavala and Biegler (2009) solves the problem in the background for a predicted state and corrects it by a sensitivity update when the measurement arrives. Both come with stability arguments that account for the approximation.

Computation is no longer the hardest part. Implementation questions are less well covered. Product specifications are often enforced on a tank or a shipment and not instant by instant, which gives an economic controller room to trade short excursions against profit, but only if the constraint is written to reflect the commercial reality. Operators accustomed to setpoints may find a controller that has none hard to supervise, because there is no simple statement of what it is trying to do. And every layer of the conventional hierarchy offers a fallback when the layer above is switched off; a merged economic layer needs a defined degraded mode. The industrial experience summarised by Qin and Badgwell (2003) suggests that such matters decide whether a controller stays in service.

Four gaps stand out. The first is evidence from plants. Simulation studies use the same model for the controller and the process, or perturb a few parameters, and so understate the effect of structural mismatch. Pilot-scale demonstrations with a deliberately varied feed would be more persuasive than further simulations. The second is estimation. Work is needed on which feed properties are observable from realistic instrumentation on a reactive column, and on how estimation error propagates into economic loss. The third is the dissipativity of real columns: for systems with known multiplicity it has seldom been established whether steady operation is optimal, and therefore whether a cycling economic controller is a fault or a feature.

The fourth gap is comparative. Self-optimising control structures, a fast steady-state optimiser with a well-tuned tracking controller, and full economic control have rarely been compared on the same column with the same disturbance scenarios and the same model error. Without such comparisons it is hard to say how much of the benefit attributed to economic control could be obtained by simpler means, and a designer has little basis for choosing among them.

Reactive distillation columns are sensitive to feed composition for structural reasons, and the conventional hierarchy responds to that disturbance slowly. Economic model predictive control addresses the delay in principle, and its theory is now mature enough to say when stable and economically sound behaviour can be expected. The application literature for reactive columns is thin, is based mainly on simulation, and leaves open the questions of disturbance estimation, model maintenance and operator supervision that will determine practical value. The case for the approach is therefore promising but not yet demonstrated, and the most useful next contributions would be experimental.

To be declared by the author(s) before publication.

To be declared by the author(s) before publication.