Hyperpigmentation of the teeth and tongue may occur in skin cancer patients receiving etoposide, prednisolone, vincristine, and cyclophosphamide treatment

Abstract

Cutaneous extranodal non-Hodgkin lymphoma is an unusual cancer that often responds to chemotherapeutic drugs including cyclophosphamide, vincristine, and etoposide. Hyperpigmentation of the nails and skin is an extremely rare side effect of these medications. A case of hyperpigmentation that extended to the tongue and teeth is shown here, however. Teeth and the tongue started to hyperpigment soon after chemotherapy began. Within a week, the hyperpigmentation cleared up without the need for any medication, surgery, or changes to one's way of life.